Mitochondrial deoxyribonucleic acid (mtDNA) is essential for cellular energy production and overall cell function. Abnormalities in mtDNA are linked to various diseases and are also implicated in ...

Bacterial transcription is a production line of copying over genetic instructions from double stranded DNA to produce RNA, which is then used for the subsequent production of proteins that the ...

The study determined that this mechanism plays a key role in gene transcription activation and macrophage functional activation. The researchers employed an in vitro nucleosome assembly system and ...

Transcription-coupled repair (TCR) represents a specialised subpathway of nucleotide excision repair that accelerates removal of lesions on the transcribed strand of active genes. In bacteria, DNA ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease and ...

RNA Polymerase III is specialised for the synthesis of short, abundant non-coding RNAs, notably transfer RNAs and 5S ribosomal RNA. Initiation requires assembly of a pre-initiation complex, comprising ...

The evolution of biomedical science can be appreciated through studies of hemoglobin, the oxygen-carrying protein in red cells. Before molecular cloning, the geneticist Arno Motulsky noted, “Many ...

This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

Scientists at the Massachusetts Institute of Technology (MIT) have invented a new single-cell nascent RNA sequencing technique that lets them observe the timing of gene and enhancer activation in ...

Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from ...

This article and associated images are based on a poster originally authored by Cristina Alli, Chiara Soldati, Ottavia Cecchetti, Monica Bisbocci, Sara Pugliese, Mauro Cerretani, Elisa Beghetto, Marta ...