In living cells, regulation of the electrochemical environment is supposed to be managed by ion channels—protein complexes that reside in cell membranes and assume definite shapes. So, it’s surprising ...

Forty years ago, a postdoctoral researcher named James McGrath who would go on to spend more than three decades as a clinical geneticist and research scientist at Yale, made a discovery that advanced ...

TDP-43 leads a varied life, interacting with a host of different RNAs and proteins as it shuttles from the nucleus to the cytoplasm and back. This offers this RNA-binding protein plenty of ...

New findings provide details about the hidden organization of the cytoplasm, showing it makes a big difference where in that cellular broth that messenger RNA (mRNA) get translated into proteins. The ...

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight. Now the lab is ...

A single protein bolted to the inner membrane of a bacterial cell can shred a virus’s DNA before that genetic material ever ...

It’s a familiar image, reprinted in countless biology textbooks: an illustration of a typical cell, halved like a grapefruit to reveal its innards. Strands of endoplasmic reticulum encircle a nucleus ...