A tissue section from a mouse model of lung metastasis showing cancer cells (green) that have attracted and activated fibroblasts (red) to support the growth of a metastatic tumor. Image: Massagué Lab ...
Schematic representation of different strategies targeting TGF-β signaling for liver fibrosis therapy. TGF-β signaling inhibitors hold important therapeutic potential for hepatic fibrosis. Although ...
When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...
CYR61, cysteine-rich angiogenic inducer 61; FT, factors of transcription; LATS, large tumor suppressor; MOB, mob kinase activator; MST, mammalian sterile 20-like ...
Liver fibrosis, a pathological scarring process resulting from chronic liver injury, represents a significant global health burden due to its potential progression to cirrhosis and hepatocellular ...
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