Proteins often function in pairs or groups, concealing their internal connection points and making it difficult for scientists to study their individual units without altering their natural structure.

Intracellular protein editing. Credit: Science (2025). DOI: 10.1126/science.adr5499. https://www.science.org/doi/10.1126/science.adr5499 University of Pennsylvania ...

Age-related changes in protein tagging and degradation may help explain how the brain declines over time and why diet can still influence these processes.

Creating analytical tools that support the advancement of knowledge can often come about through the integration of existing information and techniques, theoretical and practical, directed toward a ...

Understanding how proteins behave in living systems is central to biology. Yet, for decades, researchers have relied on overexpression models or antibody-based detection methods that can distort the ...

His-tagged proteins underpin research in structural biology, test development, and drug development. Their small tag enables easy purification and rapid construct iteration. When screening many ...

There is no known cure for Huntington's disease. A genetic mutation creates harmful proteins that accumulate and cause the disease's typical symptoms. A team from the Department of Human Genetics at ...

University of Pennsylvania researchers have developed a powerful new investigative tool to reveal how proteins work inside living cells. A technique that enables quick, precise and minimally ...