ALS is linked to toxic TDP-43 protein clumps. A new strategy targets a specific protein region. A small molecule, XL20, prevents clumping, reducing nerve damage in human cells. XL20 extended survival ...

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...

In a paper published in Proceedings of the National Academy of Sciences, researchers from Technion and Tel Aviv University ...

A new LMU study shows how proteins function reliably even without a stable 3D structure—and the crucial importance not only of short sequence motifs, but also of chemical characteristics. Many ...

Northwestern Medicine scientists have developed a new experimental method to analyze conformational fluctuations in protein domains on a uniquely large scale, which may improve data-driven modeling, ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

A new LMU study shows how proteins function reliably even without a stable 3D structure – and the crucial importance not only of short sequence motifs, but also of the chemical characteristics. Many ...

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...

A grayscale ribbon representation of a protein with space filling representations of a steroid (orange) and β-lactamase active site (green). One of the hormone-binding protein switches Credit: Kirill ...

Proteins are most well-known for their intricate structures. The α-helices and β-sheets that form from interactions between sidechains create distinct shapes that, along with the specific amino acid ...