Housekeeping σ factors are initiation factors for the bacterial RNA polymerase at most promoters, whereas alternative σs direct focused responses to specific environmental conditions. Structural and ...
Plant bioengineering—in which plant genes are modified to include desirable characteristics—is the key to solutions for problems concerning crop resilience and food security. Elements like gene ...
A recent study by the Weber-Ban and Ban groups (IMBB) published in Science Advances uncovers that the master regulator of the DNA damage response in mycobacteria, PafBC, leverages a unique mechanism ...
In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression at transcriptional and posttranscriptional levels is essential. This involves a detailed understanding and ...
Designers of cancer drugs have begun to aim their arrows at an up-and-coming series of targets in the human genome: quadruplexes, a family of DNA structures that form in sites that switch genes on ...
Background and Aim: Virologic breakthrough (VBTH) during long-term lamivudine therapy is believed to be due to the emergence of rtYM204I/VDD mutants. We observed VBTH in 17 of 67 patients receiving ...
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