Risk for ASD is strongly genetically influenced and reflects several types of genetic variation 1,2,3,4,5,6,7. Common polygenic variation, distributed across the genome, accounts for at least 20% of ...

Polygenic background bidirectionally modifies the penetrance of pathogenic variants in hypertrophic (HCM) and dilated (DCM) ...

The American Society for Reproductive Medicine published a report that concludes preimplantation genetic testing for ...

Using polygenic risk scores along with positive family histories and breast cancer-associated gene mutations improves risk stratification for breast cancer screening. Compared with a lower polygenic ...

Polygenic risk scores (PRS) combined with clinical factors improve POAG risk prediction, aiding in identifying high-risk patients. The study used OHTS data, showing low polygenic risk correlates with ...

New methods of analysis and novel markers are currently being identified to predict conditions with polygenic inheritance. These include polygenic risk scores (PRS), which are based on the presence of ...

A polygenic risk score was able to detect a high proportion of clinically significant prostate cancer. Cancer would not have been detected in 71.8% of patients with the use of PSA or MRI screening.

Opinions differ as to the value of genetic information in the form of polygenic scores and the usefulness of polygenic score analysis as part of routine healthcare – clinical utility. Views on ...

Please provide your email address to receive an email when new articles are posted on . NEW ORLEANS — Causal artificial intelligence used to augment a polygenic risk score for CAD helped estimate how ...

The Alzheimer's disease pathological cascade unfolds in the brain over decades, amidst a menagerie of cell types reacting to change. How, and when, does each cell type contribute to the process? A ...