Higher concentrations of cholesterol-containing low-density lipoprotein (LDL-C) increase the risk of cardiovascular disease (CVD). The association of LDL-C with non-CVD traits remains unclear, as are ...

Increasingly, cholesterol is implicated in diseases beyond the cardiovascular system. Major diseases of the gastrointestinal tract and liver are a case in point and are a focus of this Review.

Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. We conducted a randomized, ...

Lipoproteins consist of lipids that are chemically attached to protein conjugates called apolipoproteins. These amphipathic molecules have a central lipid core of cholesterol esters and ...

Lipoprotein(a) levels are genetically determined and, when elevated, are a risk factor for cardiovascular disease and aortic stenosis. There are no approved pharmacologic therapies to lower ...

Cholesterol is a type of lipid, or fat. It travels through the body as a lipoprotein. The two main types are high density lipoprotein (HDL) and low density lipoprotein (LDL). Cholesterol has an ...

A new analysis has uncovered a potential link between higher prostate cancer risk and genetic variants associated with higher bloodstream levels of the cholesterol-transporting molecule lipoprotein A.

Higher serum 25-hydroxyvitamin D levels were independently associated with lower LDL-C, triglycerides, and lipoprotein(a) in ...

Pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) are produced in large quantities locally in the joints and subsequently enter the bloodstream. TNF-α and IL-6 may promote LDL metabolism by ...