Antibodies—proteins that are produced by our immune system to protect us—are crucial for recognizing and getting rid of unwanted substances, or antigens, in our body. Although their role is universal, ...

Although N-linked glycans play pivotal roles in the regulation of antibody effector functions, little is known about the composition and functional impact of glycans attached to human B cell receptors ...

Immunoglobulin M (IgM) plays a critical role in both humoral and mucosal immunity. In serum, IgM is primarily found in its pentameric form, consisting of five IgM monomers linked together by the ...

Researchers at UMC Utrecht have discovered that converting monoclonal antibodies from the IgG to the IgM isotype can significantly broaden their ability to recognize and bind multiple human-relevant ...

In a recent study posted to the bioRxiv* preprint server, researchers in the Netherlands assessed the structure of human circulatory immunoglobulin M (IgM) and its relationship with the small CD5 ...

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...

Researchers have analyzed the antibody Immunoglobulin M in rainbow trout to shed some light on why these proteins may have evolved over time. Antibodies -- proteins that are produced by our immune ...