In a recent article posted to the bioRxiv* preprint server, researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major ...
Cabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor–Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group Trial ...
The immune system relies on a fine-tuned balance between the generation of peptide antigens and their presentation to cytotoxic T cells via Major Histocompatibility Complex (MHC) class I molecules.
Tasked with presenting thousands of unique antigens to T cells, the proteins that form the major histocompatibility complex arise from genes on the human leukocyte antigen (HLA) locus—the most ...
No matter where cancer cells grow in the human body, they are a threat to our health and our lives. But instead of treating them with chemotherapy or radiation—which have undesirable side effects—what ...
How does the gut cause Multiple Sclerosis? New research identifies the MHC II protein in intestinal epithelial cells as the trigger for MS-related neuroinflammation. Discover how gut-primed T cells ...
A research team has discovered a previously unknown mechanism that could explain why many patients with aggressive B-cell lymphoma do not respond to CAR-T cell therapy in the long term. The results of ...
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