Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is ...

What do cells do when they are “hungry”? Eukaryotic cells cope with starving conditions by eating their own components, a process called autophagy. Aa Aa Aa Normally, when you are hungry you look for ...

Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases ...

Lysosomes, often reductively referred to as the "garbage disposals" of cells, play a pivotal role in our cells’ digestive systems by getting rid of unwanted materials. Now in a groundbreaking study, ...

For the first time, the pathway through which cells repair damaged lysosomes has been observed and described. Lysosomes are the recycling center of a cell, where molecular waste is degraded into the ...

Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when the cellular ...

Fukuoka, Japan—The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. A lysosomal storage disorder, mucolipidosis type II causes edema of the internal ...

Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases' ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, ...