In recent decades, rapid progression of monoclonal antibody (mAb) development has culminated in approvals for more than one hundred therapeutics in the United States. mAbs enhance the immune response ...

Research and development of monoclonal antibody (mAb) therapeutics is a vast and expanding area of drug discovery, largely due to mAb potential for high specificity and affinity towards target ...

Flow cytometry offers practical advantages for real-time monitoring of CAR T cell expansion, persistence, and toxicity risk in aggressive large B-cell lymphoma patients. Early CAR T cell expansion is ...

One of the primary objectives for the application of flow cytometry in any testing environment should be measurement assurance, i.e., the generation of reliable and reproducible results. This goal can ...

Flow cytometry assay validation requires different analytical approaches in preclinical and clinical settings. A fit-for-purpose (FFP) strategy allows researchers to customize the validation to ...

Flow cytometry is a high throughput method of cell analysis that utilizes carefully designed flow systems to pass cells or other particles in a single file by a laser detector, allowing the size and ...

Setting up reliable controls is one of the priorities that any scientist should be concerned with when engaging in scientific research and experimentation. Without controls, it is nearly impossible to ...

Larry Sklar (left) is a Distinguished Professor Emeritus at the University of New Mexico (UNM; NM, USA) whose interest in flow cytometry as a tool for drug discovery led to the development of ...

Around the same time, Mack Fulwyler, an engineer working at Los Alamos National Laboratory, needed to separate particles, so he drew on existing techniques to create droplets to separate cells from a ...