Cancer metastasis is the process by which cancerous cells spread from the primary tumor site to other regions of the body. Despite advancements in cancer research, the factors driving the selective ...

Scientists in Japan may have come across a new ALS gene, according to the February 6 Cell Reports. Koichi Matsuda, University of Tokyo, and colleagues found that the enzyme peptidylarginine deiminase ...

Image Caption: The reaction mechanism of protein arginine citrullination is catalyzed by PAD. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative ...

Some stimuli induced citrullination, but none induced the hypercitrullination seen in the disease. "This was a surprising finding and suggests that the pathological citrullination occurring in the ...

Scancell Holdings said today it will partner with the Rheumatology Unit at Karolinska Institutet to explore further the scientific and clinical role of citrullinated proteins in the treatment of ...

Peptidyl-arginine deiminase 2 (PAD2) enzyme converts arginine amino acid residues in histone proteins into citrulline groups and promotes tumor cell proliferation in pancreatic ductal adenocarcinoma, ...

Our hypothesis is that exposure to particulate matter containing heavy metals (Cd, As and Mn) leads to induction and activation of peptidyl arginine deiminase 2 (PAD2) in lung macrophages and ...

The reaction mechanism of protein arginine citrullination is catalyzed by PAD. Protein citrullination in physiological and pathological processes. Chromatin opening through PAD-mediated citrullination ...

Experiments by scientists at Johns Hopkins and in Boston have unraveled two biological mechanisms as the major cause of protein citrullination in rheumatoid arthritis. Protein citrullination is ...