RIKEN researchers have succeeded in reconstituting long stretches of chromatin arrays. In this atomic force microscopy image, the reconstituted chromatin array contains about 98 nucleosomes. Credit: ...
This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...
Abstract:Cancer cells depend on coordinated changes in metabolism and epigenetic regulation to sustain growth, divide under stress, and adapt to therapy.
A major obstacle to durable cancer treatment is the ability of tumor cells to survive therapeutic pressure without acquiring genetic mutations. Rather than ...
Certain epigenetic modifications can directly control how genetic material is packed in the nucleus, RIKEN researchers have shown. This has important implications for our understanding of how genes ...
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