In summary, macrophages secrete IFN-β, activating the IFN-β-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-β-secreting ...
A new review published in Genes & Diseases highlights macrophage-targeted therapy as a promising frontier in cardiac regeneration and myocardial repair. The findings underscore the critical role of ...
Different immune cell populations influence the severity of cardiac inflammation after myocardial infarction (MI), which ...
A paper, "Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit," published in Protein & Cell uncovers a previously unappreciated ...
While these animals retain the regenerative ability throughout adulthood, most mammals, including mice and humans, lose this capacity shortly after birth. 4 Scientists are interested in determining ...
Cardiovascular disease remains the world’s biggest killer, responsible for millions of deaths every year. Most heart attacks ...
The research uncovers a previously unappreciated mechanism by which macrophages influence the fate of CFs post-MI. It demonstrates that macrophage-derived IFN-β stimulates the IFN-β-IFNAR-p-STAT1 axis ...
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