New NE-AFM method measures nuclear stiffness in living cells. It shows cancer nuclei change softness with chromatin and environment, aiding diagnosis and treatment. By employing a technique called ...

Neuroblastoma cancer cells before (left) and after (right) chemotherapy. The black threads are the cell's internal scaffolding, which breaks apart during treatment. This damage should kill the cell, ...

Sarah J. Aitken is at the Center of Molecular and Cellular Oncology, Yale Cancer Center, New Haven, Connecticut 06511, USA, and in the Department of Pathology, Yale School of Medicine, New Haven. Read ...

A new kind of microscope is giving scientists a way to watch life inside cells with a clarity that feels almost unfair.

(a) A scanning electron microscope (SEM) image of the nanoneedle probe used for the measurements. (b) Elasticity map of a 1 µm × 1 µm area on the nuclear surface, showing the change in elasticity ...