How many ways can a troponin assay come up with a false positive or a false negative? In this episode of AP Cardiology, Andrew Perry, MD, tallies it up with Robert Christenson, PhD, of the University ...

This article explores the causes of high-throughput screening assay failures, how these failures manifest in screening ...

In recent years, the frequency of clinical application and international recognition of Chinese herbal medicines have been increasing, but the effect of Chinese herbal medicines on common clinical ...

Luminescence and fluorescence-based assay methods prevail in modern HTS. Although invaluable as technologies, the problem of compound-related assay interferences such as quenching, auto-fluorescence, ...

You run the assay. The values come back off. Not catastrophically wrong, just inconsistent enough to make you doubt everything. You've checked the protocol twice. The kit hasn't expired. But the CV is ...

The US Food and Drug Administration is reminding the medical community about the potential for high levels of biotin—or vitamin B7—to interfere with certain lab tests, including cardiac troponin ...

With improved living standards and increased health awareness among Chinese residents, carbohydrate antigen 19-9 (CA 19-9) has become a routine marker in health examinations. Elevated CA 19-9 levels ...

Immunoassays used for human in vitro diagnostics (IVD) often use animal-sourced antibodies to recognize specific disease markers. A small percentage of individuals, however, may have antibodies in ...

Avoiding immunoassay interference requires blockers to be included in every immunoassay. Historically, animal-based interference blockers have been used to improve assay accuracy; however, they are ...

Increasingly accessible to academic researchers, high-throughput screening (HTS) is one of the best ways to discover starting points for new chemical probes and first-in-class drug candidates. However ...

Luminescence screening assays have become a central component of modern drug discovery workflows, particularly in high-throughput screening (HTS) environments. These assays enable rapid, sensitive ...