Genetic variants of ABCA1 (ATP-binding cassette A1), an ATP-driven transporter that pumps cholesterol out of cells, recently joined the ranks of potential risk factors for late-onset Alzheimer’s ...
Human glioblastoma cells (GaMg) were exposed to clozapine (25 μM), olanzapine (10 μM), haloperidol (10 μM) and imipramine (10 μM) for 6, 12, 24 or 48 hours. The choice of drugs and the different drug ...
Switch Therapeutics Inc. has announced its first development candidate, a liver-sparing APOE (apolipoprotein E) RNAi therapy for treatment of Alzheimer’s disease in APOE4 carriers. Switch’s ...
Despite years of study, ApoE still has secrets to give up. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers indicted ...
– Biotech expert and renowned Alzheimer’s disease researcher, David M. Holtzman, M.D., joins Switch’s Scientific Advisory Board to support advancement of company’s novel neurodegenerative pipeline – – ...
Apolipoproteins are pivotal for lipid metabolism and cardiovascular health, and their roles extend to diverse functions in the central nervous system (CNS), with implications for neurodegenerative ...
Scientists at UCL say drug developers should focus on two risk-raising variants of the Apoe gene New therapies for Alzheimer’s disease should target a particular gene linked to the condition, ...
Latin name: Ovis aries. Breed is unknown. Sheep are the most widely distributed domestic animal around the world. There are more than 200 breeds and they are raised for their wool, meat and milk. This ...
Genetic vulnerability of the CNS to pharmacological effects of chemotherapeutic drugs might play an important role in chemotherapy-induced central neurotoxicity. However, little is known regarding the ...
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