Raman imaging and scanning electron microscopy (SEM) was used to investigate acetaminophen solid dispersions prepared by hot melt extrusion (HME). This experiment confirmed that a high screw speed ...

The use of solid dispersion technology to increase the bioavailability of poorly water-soluble drugs has always been limited by processing and scale-up difficulties. A new approach may help to ...

In industrial production, the surface of the compound may become amorphous due to a small amount of structural damage. It is difficult for conventional instruments to detect this small amount of ...

Amorphous solid dispersions can overcome the pH effect encountered with oral oncology medications. Oral delivery is the preferred route of drug product administration for maximizing patient compliance ...